1dc0
From Proteopedia
(New page: 200px<br /><applet load="1dc0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dc0, resolution 1.3Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1dc0.gif|left|200px]]<br /><applet load="1dc0" size=" | + | [[Image:1dc0.gif|left|200px]]<br /><applet load="1dc0" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dc0, resolution 1.3Å" /> | caption="1dc0, resolution 1.3Å" /> | ||
'''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG'''<br /> | '''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A | + | The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition. |
==About this Structure== | ==About this Structure== | ||
| - | 1DC0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1DC0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA]. |
==Reference== | ==Reference== | ||
The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10688897 10688897] | The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10688897 10688897] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Dickerson, R | + | [[Category: Dickerson, R E.]] |
| - | [[Category: Kopka, M | + | [[Category: Kopka, M L.]] |
[[Category: Ng, H. L.]] | [[Category: Ng, H. L.]] | ||
[[Category: a-dna]] | [[Category: a-dna]] | ||
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[[Category: intermediate]] | [[Category: intermediate]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:03 2008'' |
Revision as of 10:15, 21 February 2008
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CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG
Overview
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.
About this Structure
1DC0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897
Page seeded by OCA on Thu Feb 21 12:15:03 2008
