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1ddj

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(New page: 200px<br /> <applet load="1ddj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ddj, resolution 2.0&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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'''CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN'''<br />
'''CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN'''<br />
==Overview==
==Overview==
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Activation of the serine protease plasmin from its zymogen, plasminogen, is the key step in fibrinolysis leading to blood clot dissolution. It also, plays critical roles in cell migration, such as in tumor metastasis. Here, we report the crystal structure of an inactive S741A mutant of human, plasminogen catalytic domain at 2.0 A resolution. This structure permits a, direct comparison with that of the plasmin catalytic unit. Unique, conformational differences are present between these two structures that, are not seen in other zymogen-enzyme pairs of the trypsin family. The, functional significance of these differences and the structural basis of, plasminogen activation is discussed in the light of this new structure.
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Activation of the serine protease plasmin from its zymogen, plasminogen, is the key step in fibrinolysis leading to blood clot dissolution. It also plays critical roles in cell migration, such as in tumor metastasis. Here, we report the crystal structure of an inactive S741A mutant of human plasminogen catalytic domain at 2.0 A resolution. This structure permits a direct comparison with that of the plasmin catalytic unit. Unique conformational differences are present between these two structures that are not seen in other zymogen-enzyme pairs of the trypsin family. The functional significance of these differences and the structural basis of plasminogen activation is discussed in the light of this new structure.
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1DDJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Plasmin Plasmin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DDJ OCA].
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1DDJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Plasmin Plasmin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDJ OCA].
==Reference==
==Reference==
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[[Category: plasminogen]]
[[Category: plasminogen]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:31:13 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:32 2008''

Revision as of 10:15, 21 February 2008

Image:1ddj.gif

1ddj, resolution 2.0Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN

Contents

Overview

Activation of the serine protease plasmin from its zymogen, plasminogen, is the key step in fibrinolysis leading to blood clot dissolution. It also plays critical roles in cell migration, such as in tumor metastasis. Here, we report the crystal structure of an inactive S741A mutant of human plasminogen catalytic domain at 2.0 A resolution. This structure permits a direct comparison with that of the plasmin catalytic unit. Unique conformational differences are present between these two structures that are not seen in other zymogen-enzyme pairs of the trypsin family. The functional significance of these differences and the structural basis of plasminogen activation is discussed in the light of this new structure.

Disease

Known diseases associated with this structure: Conjunctivitis, ligneous OMIM:[173350], Plasminogen Tochigi disease OMIM:[173350], Plasminogen deficiency, types I and II OMIM:[173350], Thrombophilia, dysplasminogenemic OMIM:[173350]

About this Structure

1DDJ is a Single protein structure of sequence from Homo sapiens. Active as Plasmin, with EC number 3.4.21.7 Full crystallographic information is available from OCA.

Reference

Human plasminogen catalytic domain undergoes an unusual conformational change upon activation., Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC, J Mol Biol. 2000 Jan 28;295(4):903-14. PMID:10656799

Page seeded by OCA on Thu Feb 21 12:15:32 2008

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