1dfq

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(New page: 200px<br /><applet load="1dfq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dfq, resolution 2.60&Aring;" /> '''THE HC FRAGMENT OF T...)
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[[Image:1dfq.gif|left|200px]]<br /><applet load="1dfq" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1dfq.gif|left|200px]]<br /><applet load="1dfq" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1dfq, resolution 2.60&Aring;" />
caption="1dfq, resolution 2.60&Aring;" />
'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID'''<br />
'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID'''<br />
==Overview==
==Overview==
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The entry of tetanus neurotoxin into neuronal cells proceeds through the, initial binding of the toxin to gangliosides on the cell surface. The, carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin, contains the ganglioside-binding site, which has not yet been fully, characterized. The crystal structures of native H(C) and of H(C) soaked, with carbohydrates reveal a number of binding sites and provide insight, into the possible mode of ganglioside binding.
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The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
==About this Structure==
==About this Structure==
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1DFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with SLB as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA].
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1DFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=SLB:'>SLB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA].
==Reference==
==Reference==
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[[Category: Tentoxilysin]]
[[Category: Tentoxilysin]]
[[Category: Black, I.]]
[[Category: Black, I.]]
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[[Category: Charles, I.G.]]
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[[Category: Charles, I G.]]
[[Category: Emsley, P.]]
[[Category: Emsley, P.]]
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[[Category: Fairweather, N.F.]]
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[[Category: Fairweather, N F.]]
[[Category: Fotinou, C.]]
[[Category: Fotinou, C.]]
[[Category: Hewitt, E.]]
[[Category: Hewitt, E.]]
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[[Category: Isaacs, N.W.]]
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[[Category: Isaacs, N W.]]
[[Category: Watts, C.]]
[[Category: Watts, C.]]
[[Category: SLB]]
[[Category: SLB]]
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[[Category: toxin]]
[[Category: toxin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:15:11 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:16:15 2008''

Revision as of 10:16, 21 February 2008

Image:1dfq.gif

1dfq, resolution 2.60Å

Drag the structure with the mouse to rotate

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID

Overview

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

About this Structure

1DFQ is a Single protein structure of sequence from Clostridium tetani with as ligand. Active as Tentoxilysin, with EC number 3.4.24.68 Full crystallographic information is available from OCA.

Reference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735

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