1w6u
From Proteopedia
(New page: 200px<br /> <applet load="1w6u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w6u, resolution 1.75Å" /> '''STRUCTURE OF HUMAN ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W6U is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with HXC and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.34 1.3.1.34]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6U OCA]]. | + | 1W6U is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with HXC and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/2,4-dienoyl-CoA_reductase_(NADPH) 2,4-dienoyl-CoA reductase (NADPH)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.34 1.3.1.34]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6U OCA]]. |
==Reference== | ==Reference== | ||
Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site., Alphey MS, Yu W, Byres E, Li D, Hunter WN, J Biol Chem. 2005 Jan 28;280(4):3068-77. Epub 2004 Nov 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15531764 15531764] | Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site., Alphey MS, Yu W, Byres E, Li D, Hunter WN, J Biol Chem. 2005 Jan 28;280(4):3068-77. Epub 2004 Nov 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15531764 15531764] | ||
| + | [[Category: 2,4-dienoyl-CoA reductase (NADPH)]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: short chain dehydrogenase]] | [[Category: short chain dehydrogenase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:50:47 2007'' |
Revision as of 11:46, 30 October 2007
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STRUCTURE OF HUMAN DECR TERNARY COMPLEX
Overview
Fatty acid catabolism by beta-oxidation mainly occurs in mitochondria and, to a lesser degree in peroxisomes. Poly-unsaturated fatty acids are, problematic for beta-oxidation, because the enzymes directly involved are, unable to process all the different double bond conformations and, combinations that occur naturally. In mammals, three accessory proteins, circumvent this problem by catalyzing specific isomerization and reduction, reactions. Central to this process is the NADPH-dependent 2,4-dienoyl-CoA, reductase. We present high resolution crystal structures of human, mitochondrial 2,4-dienoyl-CoA reductase in binary complex with cofactor, and the ternary complex with NADP(+) and substrate, trans-2,trans-4-dienoyl-CoA at 2.1 and 1.75 A resolution, respectively., The enzyme, a ... [(full description)]
About this Structure
1W6U is a [Single protein] structure of sequence from [Homo sapiens] with HXC and NAP as [ligands]. Active as [2,4-dienoyl-CoA reductase (NADPH)], with EC number [1.3.1.34]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site., Alphey MS, Yu W, Byres E, Li D, Hunter WN, J Biol Chem. 2005 Jan 28;280(4):3068-77. Epub 2004 Nov 6. PMID:15531764
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