3h3c
From Proteopedia
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===Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog=== | ===Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3h3c]] is a 1 chain structure of [[Focal adhesion kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3C OCA]. | |
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| + | ==See Also== | ||
| + | *[[Focal adhesion kinase|Focal adhesion kinase]] | ||
| + | *[[Tyrosine kinase|Tyrosine kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019428251</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Han, S.]] | [[Category: Han, S.]] | ||
[[Category: Mistry, A.]] | [[Category: Mistry, A.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Pyk2]] | [[Category: Pyk2]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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Revision as of 08:31, 26 July 2012
Contents |
Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog
Template:ABSTRACT PUBMED 19428251
About this Structure
3h3c is a 1 chain structure of Focal adhesion kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Walker DP, Zawistoski MP, McGlynn MA, Li JC, Kung DW, Bonnette PC, Baumann A, Buckbinder L, Houser JA, Boer J, Mistry A, Han S, Xing L, Guzman-Perez A. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3253-8. Epub 2009 Apr 24. PMID:19428251 doi:10.1016/j.bmcl.2009.04.093
