1dj8
From Proteopedia
(New page: 200px<br /><applet load="1dj8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dj8, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size=" | + | [[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dj8, resolution 2.0Å" /> | caption="1dj8, resolution 2.0Å" /> | ||
'''CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA'''<br /> | '''CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The X-ray crystal structure of the Escherichia coli stress response | + | The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions. |
==About this Structure== | ==About this Structure== | ||
| - | 1DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Burley, S | + | [[Category: Burley, S K.]] |
| - | [[Category: Gajiwala, K | + | [[Category: Gajiwala, K S.]] |
[[Category: alpha helical]] | [[Category: alpha helical]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:06 2008'' |
Revision as of 10:17, 21 February 2008
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CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA
Overview
The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.
About this Structure
1DJ8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria., Gajiwala KS, Burley SK, J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:10623550
Page seeded by OCA on Thu Feb 21 12:17:06 2008
