3h0b

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Revision as of 08:50, 26 July 2012

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Template:STRUCTURE 3h0b

Contents 1 Discovery of aminoheterocycles as a novel beta-secretase inhibitor class 2 About this Structure 3 See Also 4 Reference

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class

Template:ABSTRACT PUBMED 19409780

About this Structure

3h0b is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Stachel SJ, Coburn CA, Rush D, Jones KL, Zhu H, Rajapakse H, Graham SL, Simon A, Katharine Holloway M, Allison TJ, Munshi SK, Espeseth AS, Zuck P, Colussi D, Wolfe A, Pietrak BL, Lai MT, Vacca JP. Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2977-80. Epub 2009 Apr 18. PMID:19409780 doi:10.1016/j.bmcl.2009.04.033