2zda

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m (Protected "2zda" [edit=sysop:move=sysop])
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[[Image:2zda.png|left|200px]]
[[Image:2zda.png|left|200px]]
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{{STRUCTURE_2zda| PDB=2zda | SCENE= }}
{{STRUCTURE_2zda| PDB=2zda | SCENE= }}
===Exploring Thrombin S1 pocket===
===Exploring Thrombin S1 pocket===
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{{ABSTRACT_PUBMED_19520086}}
{{ABSTRACT_PUBMED_19520086}}
==About this Structure==
==About this Structure==
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[[2zda]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZDA OCA].
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[[2zda]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZDA OCA].
==See Also==
==See Also==
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*[[Hirudin]]
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*[[Hirudin|Hirudin]]
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*[[Thrombin|Thrombin]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19520086</ref><references group="xtra"/>
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<ref group="xtra">PMID:019520086</ref><ref group="xtra">PMID:019409395</ref><references group="xtra"/>
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[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Klebe, G.]]
[[Category: Klebe, G.]]
[[Category: Acute phase]]
[[Category: Acute phase]]
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[[Category: Blood clotting-hydrolase inhibitor complex]]
[[Category: Blood clotting/hydrolase inhibitor]]
[[Category: Blood clotting/hydrolase inhibitor]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
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[[Category: Calcium]]
 
[[Category: Cleavage on pair of basic residue]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Kringle]]
[[Category: Kringle]]
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[[Category: Polymorphism]]
 
[[Category: Protease]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]

Revision as of 09:20, 26 July 2012

Image:2zda.png

Template:STRUCTURE 2zda

Contents

Exploring Thrombin S1 pocket

Template:ABSTRACT PUBMED 19520086

About this Structure

2zda is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J Mol Biol. 2009 Aug 21;391(3):552-64. Epub 2009 Jun 9. PMID:19520086 doi:10.1016/j.jmb.2009.06.016
  • Baum B, Mohamed M, Zayed M, Gerlach C, Heine A, Hangauer D, Klebe G. More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the s1 pocket of thrombin. J Mol Biol. 2009 Jul 3;390(1):56-69. Epub 2009 May 3. PMID:19409395 doi:10.1016/j.jmb.2009.04.051

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OCA

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