1dlz
From Proteopedia
(New page: 200px<br /><applet load="1dlz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dlz" /> '''SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZER...) |
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'''SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)'''<br /> | '''SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Spatial structure of the membrane channel-forming hexadecapeptide, zervamicin IIB, was studied by NMR spectroscopy in mixed solvents of | + | Spatial structure of the membrane channel-forming hexadecapeptide, zervamicin IIB, was studied by NMR spectroscopy in mixed solvents of different polarity ranging from CDCl3/CD3OH (9:1, v/v) to CD3OH/H2O (1:1, v/v). The results show that in all solvents used the peptide has a very similar structure that is a bent amphiphilic helix with a mean backbone root mean square deviation (rmsd) value of ca. 0.3 A. Side chains of Trp1, Ile2, Gln3, Ile5 and Thr6 are mobile. The results are discussed in relation to the validity of the obtained structure to serve as a building block of zervamicin IIB ion channels. |
==About this Structure== | ==About this Structure== | ||
| - | 1DLZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Emericellopsis_salmosynnemata Emericellopsis salmosynnemata] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1DLZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Emericellopsis_salmosynnemata Emericellopsis salmosynnemata] with <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Emericellopsis salmosynnemata]] | [[Category: Emericellopsis salmosynnemata]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Arseniev, A | + | [[Category: Arseniev, A S.]] |
| - | [[Category: Balashova, T | + | [[Category: Balashova, T A.]] |
| - | [[Category: Ovchinnikova, T | + | [[Category: Ovchinnikova, T V.]] |
[[Category: Raap, J.]] | [[Category: Raap, J.]] | ||
| - | [[Category: Shenkarev, Z | + | [[Category: Shenkarev, Z O.]] |
| - | [[Category: Tagaev, A | + | [[Category: Tagaev, A A.]] |
[[Category: ACE]] | [[Category: ACE]] | ||
[[Category: antibiotic]] | [[Category: antibiotic]] | ||
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[[Category: zervamicin]] | [[Category: zervamicin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:18:02 2008'' |
Revision as of 10:18, 21 February 2008
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SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)
Overview
Spatial structure of the membrane channel-forming hexadecapeptide, zervamicin IIB, was studied by NMR spectroscopy in mixed solvents of different polarity ranging from CDCl3/CD3OH (9:1, v/v) to CD3OH/H2O (1:1, v/v). The results show that in all solvents used the peptide has a very similar structure that is a bent amphiphilic helix with a mean backbone root mean square deviation (rmsd) value of ca. 0.3 A. Side chains of Trp1, Ile2, Gln3, Ile5 and Thr6 are mobile. The results are discussed in relation to the validity of the obtained structure to serve as a building block of zervamicin IIB ion channels.
About this Structure
1DLZ is a Protein complex structure of sequences from Emericellopsis salmosynnemata with as ligand. Full crystallographic information is available from OCA.
Reference
NMR structure of the channel-former zervamicin IIB in isotropic solvents., Balashova TA, Shenkarev ZO, Tagaev AA, Ovchinnikova TV, Raap J, Arseniev AS, FEBS Lett. 2000 Jan 28;466(2-3):333-6. PMID:10682854
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