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2bl0
From Proteopedia
(New page: 200px<br /> <applet load="2bl0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bl0, resolution 1.75Å" /> '''PHYSARUM POLYCEPHAL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BL0 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.32 3.6.1.32]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BL0 OCA]]. | + | 2BL0 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_3.6.4.1 Transferred entry: 3.6.4.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.32 3.6.1.32]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BL0 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Physarum polycephalum]] | [[Category: Physarum polycephalum]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Transferred entry: 3.6.4.1]] | ||
[[Category: Debreczeni, J.E.]] | [[Category: Debreczeni, J.E.]] | ||
[[Category: Farkas, L.]] | [[Category: Farkas, L.]] | ||
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[[Category: slime mould]] | [[Category: slime mould]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:51:38 2007'' |
Revision as of 11:46, 30 October 2007
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PHYSARUM POLYCEPHALUM MYOSIN II REGULATORY DOMAIN
Overview
We have previously identified a single inhibitory Ca2+-binding site in the, first EF-hand of the essential light chain of Physarum conventional myosin, (Farkas, L., Malnasi-Csizmadia, A., Nakamura, A., Kohama, K., and Nyitray, L. (2003) J. Biol. Chem. 278, 27399-27405). As a general rule, conformation of the EF-hand-containing domains in the calmodulin family is, "closed" in the absence and "open" in the presence of bound cations; a, notable exception is the unusual Ca2+-bound closed domain in the essential, light chain of the Ca2+-activated scallop muscle myosin. Here we have, reported the 1.8 A resolution structure of the regulatory domain (RD) of, Physarum myosin II in which Ca2+ is bound to a canonical EF-hand that is, also in a closed state. The 12th position of the EF-hand loop, ... [(full description)]
About this Structure
2BL0 is a [Protein complex] structure of sequences from [Physarum polycephalum] with CA as [ligand]. Active as [Transferred entry: 3.6.4.1], with EC number [3.6.1.32]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural evidence for non-canonical binding of Ca2+ to a canonical EF-hand of a conventional myosin., Debreczeni JE, Farkas L, Harmat V, Hetenyi C, Hajdu I, Zavodszky P, Kohama K, Nyitray L, J Biol Chem. 2005 Dec 16;280(50):41458-64. Epub 2005 Oct 13. PMID:16227209
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