1ax8
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ax8.png|left|200px]] | [[Image:1ax8.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_1ax8", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_1ax8| PDB=1ax8 | SCENE= }} | {{STRUCTURE_1ax8| PDB=1ax8 | SCENE= }} | ||
===Human obesity protein, leptin=== | ===Human obesity protein, leptin=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_9144295}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 9144295 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_9144295}} | {{ABSTRACT_PUBMED_9144295}} | ||
| Line 23: | Line 12: | ||
==See Also== | ==See Also== | ||
*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]] | *[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]] | ||
| - | *[[Leptin (Hebrew)|Leptin (Hebrew)]] | ||
| - | *[[User:Mary Ball/Leptin|User:Mary Ball/Leptin]] | ||
*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]] | *[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]] | ||
Revision as of 09:35, 26 July 2012
| |||||||||
| 1ax8, resolution 2.40Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | OBESE GENE (Homo sapiens) | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Human obesity protein, leptin
Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest. Most human obesity does not appear to result from a mutant form of leptin: rather, serum leptin concentrations are increased and there is an apparent inability to transport it to the central nervous system (CNS). Injection of leptin into the CNS of overfed rodents resistant to peripheral administration was found to induce biological activity. Consequently, for the leptin to act as a weight-lowering hormone in human obesity, it appears that appropriate concentrations must be present in the CNS. This places a premium on understanding the structure of the hormone in order to design more potent and selective agonists. Here we report the crystal structure at 2.4A resolution of a human mutant OB protein (leptin-E100) that has comparable biological activity to wild type but which crystallizes more readily. The structure reveals a four-helix bundle similar to that of the long-chain helical cytokine family.
Crystal structure of the obese protein leptin-E100., Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW, Nature. 1997 May 8;387(6629):206-9. PMID:9144295
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1ax8 is a 1 chain structure of Flock house virus B2 protein Suppression of RNA Silencing with sequence from Homo sapiens. The May 2012 RCSB PDB Molecule of the Month feature on Leptin by David Goodsell is 10.2210/rcsb_pdb/mom_2012_5. Full crystallographic information is available from OCA.
See Also
- Flock house virus B2 protein Suppression of RNA Silencing
- User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing
Reference
- Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature. 1997 May 8;387(6629):206-9. PMID:9144295 doi:10.1038/387206a0
- Shortle D. Composites of local structure propensities: evidence for local encoding of long-range structure. Protein Sci. 2002 Jan;11(1):18-26. PMID:11742118
- Hill EE, Morea V, Chothia C. Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. J Mol Biol. 2002 Sep 6;322(1):205-33. PMID:12215425
