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1dnm

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(New page: 200px<br /><applet load="1dnm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dnm, resolution 2.500&Aring;" /> '''CRYSTAL STRUCTURE A...)
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[[Image:1dnm.gif|left|200px]]<br /><applet load="1dnm" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1dnm, resolution 2.500&Aring;" />
caption="1dnm, resolution 2.500&Aring;" />
'''CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)'''<br />
'''CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)'''<br />
==Overview==
==Overview==
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The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been, determined to a resolution of 2.5 A and refined to an R factor of 19.3%, for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center, hydrogen bonds to pyrimidines that induce perturbations in base-pair, geometry. The central AGCT region of the helix has a wide (greater than 6, A) minor groove.
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The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.
==About this Structure==
==About this Structure==
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1DNM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DNM OCA].
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1DNM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DNM OCA].
==Reference==
==Reference==
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2395870 2395870]
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2395870 2395870]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Li, B.F.]]
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[[Category: Li, B F.]]
[[Category: Neidle, S.]]
[[Category: Neidle, S.]]
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[[Category: Sanderson, M.R.]]
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[[Category: Sanderson, M R.]]
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[[Category: Skelly, J.V.]]
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[[Category: Skelly, J V.]]
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[[Category: Swann, P.F.]]
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[[Category: Swann, P F.]]
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[[Category: Tickle, I.J.]]
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[[Category: Tickle, I J.]]
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[[Category: Webster, G.D.]]
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[[Category: Webster, G D.]]
[[Category: b-dna]]
[[Category: b-dna]]
[[Category: double helix]]
[[Category: double helix]]
[[Category: mismatched]]
[[Category: mismatched]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:23:55 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:18:28 2008''

Revision as of 10:18, 21 February 2008

Image:1dnm.gif

1dnm, resolution 2.500Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)

Overview

The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.

About this Structure

1DNM is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:2395870

Page seeded by OCA on Thu Feb 21 12:18:28 2008

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