1dpl
From Proteopedia
(New page: 200px<br /><applet load="1dpl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dpl, resolution 0.83Å" /> '''A-DNA DECAMER GCGTA(...) |
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| - | [[Image:1dpl.gif|left|200px]]<br /><applet load="1dpl" size=" | + | [[Image:1dpl.gif|left|200px]]<br /><applet load="1dpl" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dpl, resolution 0.83Å" /> | caption="1dpl, resolution 0.83Å" /> | ||
'''A-DNA DECAMER GCGTA(T23)TACGC WITH INCORPORATED 2'-METHOXY-3'-METHYLENEPHOSPHATE-THYMIDINE'''<br /> | '''A-DNA DECAMER GCGTA(T23)TACGC WITH INCORPORATED 2'-METHOXY-3'-METHYLENEPHOSPHATE-THYMIDINE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined single crystal structures of an A-DNA decamer and a | + | We have determined single crystal structures of an A-DNA decamer and a B-DNA dodecamer at 0.83 and 0.95 A, respectively. The resolution of the former is the highest reported thus far for any right-handed nucleic acid duplex and the quality of the diffraction data allowed determination of the structure with direct methods. The structures reveal unprecedented details of DNA fine structure and hydration; in particular, we have reexamined the overall hydration of A- and B-form DNA, the distribution of water around phosphate groups, and features of the water structure that may underlie the B to A transition. |
==About this Structure== | ==About this Structure== | ||
| - | 1DPL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with SPM and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1DPL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SPM:'>SPM</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: An, H.]] | [[Category: An, H.]] | ||
| - | [[Category: Cook, P | + | [[Category: Cook, P Dan.]] |
[[Category: Egli, M.]] | [[Category: Egli, M.]] | ||
[[Category: Joachimiak, A.]] | [[Category: Joachimiak, A.]] | ||
| - | [[Category: Maier, M | + | [[Category: Maier, M A.]] |
[[Category: Manoharan, M.]] | [[Category: Manoharan, M.]] | ||
[[Category: Miller, R.]] | [[Category: Miller, R.]] | ||
| Line 23: | Line 23: | ||
[[Category: Teplova, M.]] | [[Category: Teplova, M.]] | ||
[[Category: Tereshko, V.]] | [[Category: Tereshko, V.]] | ||
| - | [[Category: Weeks, C | + | [[Category: Weeks, C M.]] |
[[Category: MG]] | [[Category: MG]] | ||
[[Category: SPM]] | [[Category: SPM]] | ||
[[Category: deoxyribonucleic acid]] | [[Category: deoxyribonucleic acid]] | ||
| - | [[Category: modified a-decamer at 0 | + | [[Category: modified a-decamer at 0 83 a resolution]] |
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:04 2008'' |
Revision as of 10:19, 21 February 2008
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A-DNA DECAMER GCGTA(T23)TACGC WITH INCORPORATED 2'-METHOXY-3'-METHYLENEPHOSPHATE-THYMIDINE
Overview
We have determined single crystal structures of an A-DNA decamer and a B-DNA dodecamer at 0.83 and 0.95 A, respectively. The resolution of the former is the highest reported thus far for any right-handed nucleic acid duplex and the quality of the diffraction data allowed determination of the structure with direct methods. The structures reveal unprecedented details of DNA fine structure and hydration; in particular, we have reexamined the overall hydration of A- and B-form DNA, the distribution of water around phosphate groups, and features of the water structure that may underlie the B to A transition.
About this Structure
1DPL is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution., Egli M, Tereshko V, Teplova M, Minasov G, Joachimiak A, Sanishvili R, Weeks CM, Miller R, Maier MA, An H, Dan Cook P, Manoharan M, Biopolymers. 1998;48(4):234-52. PMID:10699842
Page seeded by OCA on Thu Feb 21 12:19:04 2008
