1o0d
From Proteopedia
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{{STRUCTURE_1o0d| PDB=1o0d | SCENE= }} | {{STRUCTURE_1o0d| PDB=1o0d | SCENE= }} | ||
===Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor=== | ===Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor=== | ||
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{{ABSTRACT_PUBMED_12781189}} | {{ABSTRACT_PUBMED_12781189}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1o0d]] is a 3 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0D OCA]. | |
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| + | ==See Also== | ||
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:012781189</ref><references group="xtra"/> |
| + | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Mack, H.]] | [[Category: Mack, H.]] | ||
[[Category: Seitz, W.]] | [[Category: Seitz, W.]] | ||
| + | [[Category: Blood clotting-hydrolase inhibitor complex]] | ||
[[Category: Ternary complex]] | [[Category: Ternary complex]] | ||
| - | [[Category: Thrombin | + | [[Category: Thrombin-active-site inhibitor-exo-site inhibitor]] |
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Revision as of 10:18, 26 July 2012
Contents |
Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
Template:ABSTRACT PUBMED 12781189
About this Structure
1o0d is a 3 chain structure of Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW. D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189
