1dqe
From Proteopedia
(New page: 200px<br /><applet load="1dqe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dqe, resolution 1.8Å" /> '''BOMBYX MORI PHEROMONE...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1dqe.gif|left|200px]]<br /><applet load="1dqe" size=" | + | [[Image:1dqe.gif|left|200px]]<br /><applet load="1dqe" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dqe, resolution 1.8Å" /> | caption="1dqe, resolution 1.8Å" /> | ||
'''BOMBYX MORI PHEROMONE BINDING PROTEIN'''<br /> | '''BOMBYX MORI PHEROMONE BINDING PROTEIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | BACKGROUND: Insects use volatile organic molecules to communicate messages | + | BACKGROUND: Insects use volatile organic molecules to communicate messages with remarkable sensitivity and specificity. In one of the most studied systems, female silkworm moths (Bombyx mori) attract male mates with the pheromone bombykol, a volatile 16-carbon alcohol. In the male moth's antennae, a pheromone-binding protein conveys bombykol to a membrane-bound receptor on a nerve cell. The structure of the pheromone-binding protein, its binding and recognition of bombykol, and its full role in signal transduction are not known. RESULTS: The three-dimensional structure of the B. mori pheromone-binding protein with bound bombykol has been determined by X-ray diffraction at 1.8 A resolution. CONCLUSIONS: The pheromone binding protein of B. mori has six helices, and bombykol binds in a completely enclosed hydrophobic cavity formed by four antiparallel helices. Bombykol is bound in this cavity through numerous hydrophobic interactions, and sequence alignments suggest critical residues for specific pheromone binding. |
==About this Structure== | ==About this Structure== | ||
| - | 1DQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori] with BOM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1DQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori] with <scene name='pdbligand=BOM:'>BOM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQE OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clardy, J.]] | [[Category: Clardy, J.]] | ||
| - | [[Category: Leal, W | + | [[Category: Leal, W S.]] |
[[Category: Nikonova, L.]] | [[Category: Nikonova, L.]] | ||
| - | [[Category: Sandler, B | + | [[Category: Sandler, B H.]] |
[[Category: BOM]] | [[Category: BOM]] | ||
[[Category: helical bundle]] | [[Category: helical bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:24 2008'' |
Revision as of 10:19, 21 February 2008
|
BOMBYX MORI PHEROMONE BINDING PROTEIN
Overview
BACKGROUND: Insects use volatile organic molecules to communicate messages with remarkable sensitivity and specificity. In one of the most studied systems, female silkworm moths (Bombyx mori) attract male mates with the pheromone bombykol, a volatile 16-carbon alcohol. In the male moth's antennae, a pheromone-binding protein conveys bombykol to a membrane-bound receptor on a nerve cell. The structure of the pheromone-binding protein, its binding and recognition of bombykol, and its full role in signal transduction are not known. RESULTS: The three-dimensional structure of the B. mori pheromone-binding protein with bound bombykol has been determined by X-ray diffraction at 1.8 A resolution. CONCLUSIONS: The pheromone binding protein of B. mori has six helices, and bombykol binds in a completely enclosed hydrophobic cavity formed by four antiparallel helices. Bombykol is bound in this cavity through numerous hydrophobic interactions, and sequence alignments suggest critical residues for specific pheromone binding.
About this Structure
1DQE is a Single protein structure of sequence from Bombyx mori with as ligand. Full crystallographic information is available from OCA.
Reference
Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex., Sandler BH, Nikonova L, Leal WS, Clardy J, Chem Biol. 2000 Feb;7(2):143-51. PMID:10662696
Page seeded by OCA on Thu Feb 21 12:19:24 2008
