3dd1
From Proteopedia
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===Crystal structure of glycogen phophorylase complexed with an anthranilimide based inhibitor GSK254=== | ===Crystal structure of glycogen phophorylase complexed with an anthranilimide based inhibitor GSK254=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Glycogen storage disease VI OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=232700 232700]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3dd1]] is a 2 chain structure of [[Glycogen Phosphorylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DD1 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Glycogen Phosphorylase|Glycogen Phosphorylase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019138846</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphorylase]] | [[Category: Phosphorylase]] | ||
[[Category: Nolte, R T.]] | [[Category: Nolte, R T.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
[[Category: Carbohydrate metabolism]] | [[Category: Carbohydrate metabolism]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Pyridoxal phosphate]] | [[Category: Pyridoxal phosphate]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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Revision as of 10:20, 26 July 2012
Contents |
Crystal structure of glycogen phophorylase complexed with an anthranilimide based inhibitor GSK254
Template:ABSTRACT PUBMED 19138846
About this Structure
3dd1 is a 2 chain structure of Glycogen Phosphorylase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Thomson SA, Banker P, Bickett DM, Boucheron JA, Carter HL, Clancy DC, Cooper JP, Dickerson SH, Garrido DM, Nolte RT, Peat AJ, Sheckler LR, Sparks SM, Tavares FX, Wang L, Wang TY, Weiel JE. Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1177-82. Epub 2008 Dec 25. PMID:19138846 doi:10.1016/j.bmcl.2008.12.085
Categories: Homo sapiens | Phosphorylase | Nolte, R T. | Allosteric enzyme | Carbohydrate metabolism | Diabetes | Disease mutation | Glycogen metabolism | Glycogen phosphorylase hlgp | Glycogen storage disease | Glycosyltransferase | Nucleotide-binding | Phosphoprotein | Pyridoxal phosphate | Transferase
