3bym

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[[Image:3bym.png|left|200px]]
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{{STRUCTURE_3bym| PDB=3bym | SCENE= }}
{{STRUCTURE_3bym| PDB=3bym | SCENE= }}
===X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck===
===X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck===
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{{ABSTRACT_PUBMED_18278858}}
{{ABSTRACT_PUBMED_18278858}}
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==Disease==
 
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Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
 
==About this Structure==
==About this Structure==
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3BYM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYM OCA].
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[[3bym]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYM OCA].
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==See Also==
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*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
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*[[Tyrosine kinase|Tyrosine kinase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:18278858</ref><references group="xtra"/>
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<ref group="xtra">PMID:018278858</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Huang, X.]]
[[Category: Huang, X.]]
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[[Category: Alternative splicing]]
 
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Chromosomal rearrangement]]
 
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[[Category: Cytoplasm]]
 
[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Host-virus interaction]]
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:10:23 2009''
 

Revision as of 10:23, 26 July 2012

Image:3bym.png

Template:STRUCTURE 3bym

Contents

X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck

Template:ABSTRACT PUBMED 18278858

About this Structure

3bym is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG. Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:18278858 doi:10.1021/jm701095m

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OCA

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