1dqt
From Proteopedia
(New page: 200px<br /><applet load="1dqt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dqt, resolution 2.0Å" /> '''THE CRYSTAL STRUCTURE...) |
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| - | [[Image:1dqt.gif|left|200px]]<br /><applet load="1dqt" size=" | + | [[Image:1dqt.gif|left|200px]]<br /><applet load="1dqt" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dqt, resolution 2.0Å" /> | caption="1dqt, resolution 2.0Å" /> | ||
'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''<br /> | '''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The effective regulation of T cell responses is dependent on opposing | + | The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin superfamily and displays a strand topology similar to Valpha domains, with an unusual mode of dimerization that places the B7 binding sites distal to the dimerization interface. This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness. |
==About this Structure== | ==About this Structure== | ||
| - | 1DQT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CL and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1DQT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Almo, S | + | [[Category: Almo, S C.]] |
| - | [[Category: Nathenson, S | + | [[Category: Nathenson, S G.]] |
| - | [[Category: Ostrov, D | + | [[Category: Ostrov, D A.]] |
| - | [[Category: Schwartz, J | + | [[Category: Schwartz, J C.]] |
[[Category: Shi, W.]] | [[Category: Shi, W.]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: immunoglobulin variable domain-like beta-sandwich]] | [[Category: immunoglobulin variable domain-like beta-sandwich]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:28 2008'' |
Revision as of 10:19, 21 February 2008
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THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)
Overview
The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin superfamily and displays a strand topology similar to Valpha domains, with an unusual mode of dimerization that places the B7 binding sites distal to the dimerization interface. This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness.
About this Structure
1DQT is a Single protein structure of sequence from Mus musculus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:11052947
Page seeded by OCA on Thu Feb 21 12:19:28 2008
