1dus
From Proteopedia
(New page: 200px<br /><applet load="1dus" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dus, resolution 1.80Å" /> '''MJ0882-A hypothetica...) |
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| - | [[Image:1dus.gif|left|200px]]<br /><applet load="1dus" size=" | + | [[Image:1dus.gif|left|200px]]<br /><applet load="1dus" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dus, resolution 1.80Å" /> | caption="1dus, resolution 1.80Å" /> | ||
'''MJ0882-A hypothetical protein from M. jannaschii'''<br /> | '''MJ0882-A hypothetical protein from M. jannaschii'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the three-dimensional (3-D) structure of protein | + | We have determined the three-dimensional (3-D) structure of protein MJ0882, which derives from a hypothetical open reading frame in the genome of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882 at 1.8 A highly resembles that of a methyltransferase, despite limited sequence similarity to any confirmed methyltransferase. The structure has an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with similarities to those commonly found among AdoMet binding proteins. Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases. |
==About this Structure== | ==About this Structure== | ||
| - | 1DUS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http:// | + | 1DUS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Methanocaldococcus jannaschii]] | [[Category: Methanocaldococcus jannaschii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: BSGC, Berkeley | + | [[Category: BSGC, Berkeley Structural Genomics Center.]] |
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
[[Category: Hung, L.]] | [[Category: Hung, L.]] | ||
[[Category: Kim, R.]] | [[Category: Kim, R.]] | ||
| - | [[Category: Kim, S | + | [[Category: Kim, S H.]] |
[[Category: berkeley structural genomics center]] | [[Category: berkeley structural genomics center]] | ||
[[Category: bsgc structure funded by nih]] | [[Category: bsgc structure funded by nih]] | ||
| Line 26: | Line 26: | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:20:40 2008'' |
Revision as of 10:20, 21 February 2008
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MJ0882-A hypothetical protein from M. jannaschii
Overview
We have determined the three-dimensional (3-D) structure of protein MJ0882, which derives from a hypothetical open reading frame in the genome of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882 at 1.8 A highly resembles that of a methyltransferase, despite limited sequence similarity to any confirmed methyltransferase. The structure has an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with similarities to those commonly found among AdoMet binding proteins. Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases.
About this Structure
1DUS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii., Huang L, Hung L, Odell M, Yokota H, Kim R, Kim SH, J Struct Funct Genomics. 2002;2(3):121-7. PMID:12836702
Page seeded by OCA on Thu Feb 21 12:20:40 2008
Categories: Methanocaldococcus jannaschii | Single protein | BSGC, Berkeley Structural Genomics Center. | Huang, L. | Hung, L. | Kim, R. | Kim, S H. | Berkeley structural genomics center | Bsgc structure funded by nih | Hypothetical protein | Methanococcus jannaschii | Protein structure initiative | Psi | Structural genomics
