3kl6
From Proteopedia
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===Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor=== | ===Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor=== | ||
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{{ABSTRACT_PUBMED_20355714}} | {{ABSTRACT_PUBMED_20355714}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227600 227600]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3kl6]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL6 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Factor Xa|Factor Xa]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020355714</ref><references group="xtra"/> |
[[Category: Coagulation factor Xa]] | [[Category: Coagulation factor Xa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aertgeerts, K.]] | [[Category: Aertgeerts, K.]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Coagulation factor xa]] | [[Category: Coagulation factor xa]] | ||
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[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydroxylation]] | [[Category: Hydroxylation]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:06:26 2010'' | ||
Revision as of 11:31, 26 July 2012
Contents |
Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor
Template:ABSTRACT PUBMED 20355714
About this Structure
3kl6 is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Fujimoto T, Imaeda Y, Konishi N, Hiroe K, Kawamura M, Textor GP, Aertgeerts K, Kubo K. Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor. J Med Chem. 2010 May 13;53(9):3517-31. PMID:20355714 doi:10.1021/jm901699j
Categories: Coagulation factor Xa | Homo sapiens | Aertgeerts, K. | Blood coagulation | Cleavage on pair of basic residue | Coagulation factor xa | Disulfide bond | Egf-like domain | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydroxylation | Protease | Secreted | Serine protease | Zymogen
