1gl4
From Proteopedia
(New page: 200px<br /> <applet load="1gl4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gl4, resolution 2.00Å" /> '''NIDOGEN-1 G2/PERLEC...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GL4 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with ZN and EPE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GL4 OCA]]. | + | 1GL4 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with ZN and EPE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: EPE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GL4 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: proteoglycan]] | [[Category: proteoglycan]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:53:04 2007'' |
Revision as of 11:48, 30 October 2007
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NIDOGEN-1 G2/PERLECAN IG3 COMPLEX
Overview
Nidogen and perlecan are large multifunctional basement membrane (BM), proteins conserved in all metazoa. Their high-affinity interaction, which, is likely to contribute to BM assembly and function, is mediated by the, central G2 domain in nidogen and the third immunoglobulin (IG)-like domain, in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution, of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to, the I-set of the IG superfamily and binds to the wall of the nidogen-1 G2, beta-barrel using beta-strands C, D and F. Nidogen-1 residues, participating in the extensive interface are highly conserved, whereas the, corresponding binding site on perlecan is more variable. We hypothesize, that a second, as yet unidentified, activity of nidogen overlaps ... [(full description)]
About this Structure
1GL4 is a [Protein complex] structure of sequences from [Mus musculus] with ZN and EPE as [ligands]. Structure known Active Site: EPE. Full crystallographic information is available from [OCA].
Reference
Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan., Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E, EMBO J. 2001 Oct 1;20(19):5342-6. PMID:11574465
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