3ivh

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Revision as of 11:42, 26 July 2012

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Template:STRUCTURE 3ivh

Contents 1 Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents 2 About this Structure 3 See Also 4 Reference

Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents

Template:ABSTRACT PUBMED 19811916

About this Structure

3ivh is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Sealy JM, Truong AP, Tso L, Probst GD, Aquino J, Hom RK, Jagodzinska BM, Dressen D, Wone DW, Brogley L, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Dappen MS, Toth G, Pan H, Ruslim L, Miller J, Bova MP, Sinha S, Quinn KP, Sauer JM. Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6386-91. Epub 2009 Sep 19. PMID:19811916 doi:10.1016/j.bmcl.2009.09.061