1gl3
From Proteopedia
(New page: 200px<br /> <applet load="1gl3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gl3, resolution 2.6Å" /> '''ASPARTATE BETA-SEMIA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GL3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with CYS and NDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GL3 OCA]]. | + | 1GL3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with CYS and NDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11]]. Structure known Active Site: AT1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GL3 OCA]]. |
==Reference== | ==Reference== | ||
Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase., Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE, Biochemistry. 2001 Dec 4;40(48):14475-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11724560 11724560] | Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase., Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE, Biochemistry. 2001 Dec 4;40(48):14475-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11724560 11724560] | ||
| + | [[Category: Aspartate-semialdehyde dehydrogenase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:53:14 2007'' |
Revision as of 11:48, 30 October 2007
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ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE IN COMPLEX WITH NADP AND SUBSTRATE ANALOGUE S-METHYL CYSTEINE SULFOXIDE
Overview
Aspartate-beta-semialdehyde dehydrogenase (ASADH) lies at the first branch, point in the biosynthetic pathway through which bacteria, fungi, and the, higher plants synthesize amino acids, including lysine and methionine and, the cell wall component diaminopimelate from aspartate. Blocks in this, biosynthetic pathway, which is absent in mammals, are lethal, and, inhibitors of ASADH may therefore serve as useful antibacterial, fungicidal, or herbicidal agents. We have determined the structure of, ASADH from Escherichia coli by crystallography in the presence of its, coenzyme and a substrate analogue that acts as a covalent inhibitor. This, structure is comparable to that of the covalent intermediate that forms, during the reaction catalyzed by ASADH. The key catalytic residues are, ... [(full description)]
About this Structure
1GL3 is a [Single protein] structure of sequence from [Escherichia coli] with CYS and NDP as [ligands]. Active as [Aspartate-semialdehyde dehydrogenase], with EC number [1.2.1.11]. Structure known Active Site: AT1. Full crystallographic information is available from [OCA].
Reference
Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase., Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE, Biochemistry. 2001 Dec 4;40(48):14475-83. PMID:11724560
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