1vhr
From Proteopedia
(New page: 200px<br /> <applet load="1vhr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vhr, resolution 2.1Å" /> '''HUMAN VH1-RELATED DU...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1VHR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and EPE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VHR OCA]]. | + | 1VHR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and EPE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Structure known Active Sites: GAA, GAB, PLA, PLB, RCA, RCB, VRA and VRB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VHR OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8650541 8650541] | Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8650541 8650541] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Denu, J.M.]] | [[Category: Denu, J.M.]] | ||
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[[Category: protein dual-specificity phosphatase]] | [[Category: protein dual-specificity phosphatase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:53:30 2007'' |
Revision as of 11:48, 30 October 2007
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HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE
Overview
Dual specificity protein phosphatases (DSPs) regulate mitogenic signal, transduction and control the cell cycle. Here, the crystal structure of a, human DSP, vaccinia H1-related phosphatase (or VHR), was determined at 2.1, angstrom resolution. A shallow active site pocket in VHR allows for the, hydrolysis of phosphorylated serine, threonine, or tyrosine protein, residues, whereas the deeper active site of protein tyrosine phosphatases, (PTPs) restricts substrate specificity to only phosphotyrosine. Positively, charged crevices near the active site may explain the enzyme's preference, for substrates with two phosphorylated residues. The VHR structure defines, a conserved structural scaffold for both DSPs and PTPs. A "recognition, region," connecting helix alpha1 to strand beta1, may ... [(full description)]
About this Structure
1VHR is a [Single protein] structure of sequence from [Homo sapiens] with SO4 and EPE as [ligands]. Active as [Protein-tyrosine-phosphatase], with EC number [3.1.3.48]. Structure known Active Sites: GAA, GAB, PLA, PLB, RCA, RCB, VRA and VRB. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:8650541
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