1dzl
From Proteopedia
(New page: 200px<br /><applet load="1dzl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dzl, resolution 3.50Å" /> '''L1 PROTEIN OF HUMAN ...) |
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| - | [[Image:1dzl.gif|left|200px]]<br /><applet load="1dzl" size=" | + | [[Image:1dzl.gif|left|200px]]<br /><applet load="1dzl" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dzl, resolution 3.50Å" /> | caption="1dzl, resolution 3.50Å" /> | ||
'''L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16'''<br /> | '''L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The papillomavirus major late protein, L1, forms the pentameric assembly | + | The papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and truncation of ten N-terminal residues leads to a homogeneous preparation of 12-pentamer, icosahedral particles. X-ray crystallographic analysis of these particles at 3.5 A resolution shows that L1 closely resembles VP1 from polyomaviruses. Surface loops contain the sites of sequence variation among HPV types and the locations of dominant neutralizing epitopes. The ease with which small virus-like particles may be obtained from L1 expressed in E. coli makes them attractive candidate components of a papillomavirus vaccine. Their crystal structure also provides a starting point for future vaccine design. |
==About this Structure== | ==About this Structure== | ||
| - | 1DZL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_13 Human papillomavirus type 13]. Full crystallographic information is available from [http:// | + | 1DZL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_13 Human papillomavirus type 13]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human papillomavirus type 13]] | [[Category: Human papillomavirus type 13]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Chen, X | + | [[Category: Chen, X J.]] |
[[Category: Garcea, B.]] | [[Category: Garcea, B.]] | ||
[[Category: Goldberge, I.]] | [[Category: Goldberge, I.]] | ||
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
[[Category: icosahedral]] | [[Category: icosahedral]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:11 2008'' |
Revision as of 10:22, 21 February 2008
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L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16
Overview
The papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and truncation of ten N-terminal residues leads to a homogeneous preparation of 12-pentamer, icosahedral particles. X-ray crystallographic analysis of these particles at 3.5 A resolution shows that L1 closely resembles VP1 from polyomaviruses. Surface loops contain the sites of sequence variation among HPV types and the locations of dominant neutralizing epitopes. The ease with which small virus-like particles may be obtained from L1 expressed in E. coli makes them attractive candidate components of a papillomavirus vaccine. Their crystal structure also provides a starting point for future vaccine design.
About this Structure
1DZL is a Single protein structure of sequence from Human papillomavirus type 13. Full crystallographic information is available from OCA.
Reference
Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:10882140
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