1h22

(Difference between revisions)

Revision as of 12:35, 26 July 2012

1h22 is a 1 chain structure of Acetylcholinesterase with sequence from Torpedo californica. Full crystallographic information is available from OCA.

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15;125(2):363-73. PMID:12517147 doi:http://dx.doi.org/10.1021/ja021111w
Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP. Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1. Angew Chem Int Ed Engl. 2000 May 15;39(10):1775-1777. PMID:10934357
Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat Struct Biol. 1997 Jan;4(1):57-63. PMID:8989325
Pang YP, Kozikowski AP. Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies. J Comput Aided Mol Des. 1994 Dec;8(6):669-81. PMID:7738603
Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science. 1991 Aug 23;253(5022):872-9. PMID:1678899

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 [[Image:1h22.png|left|200px]]
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 {{STRUCTURE_1h22|  PDB=1h22  |  SCENE=  }}
 ===STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(10)-HUPYRIDONE AT 2.15A RESOLUTION===
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 *[[AChE bivalent inhibitors|AChE bivalent inhibitors]]
 *[[Acetylcholinesterase|Acetylcholinesterase]]
-*[[Alzheimer's Disease|Alzheimer's Disease]]
 *[[Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor|Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor]]
 *[[User:Dawn M. Wong|User:Dawn M. Wong]]