1e31
From Proteopedia
(New page: 200px<br /> <applet load="1e31" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e31, resolution 2.71Å" /> '''SURVIVIN DIMER H. S...) |
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| - | [[Image:1e31.gif|left|200px]]<br /> | + | [[Image:1e31.gif|left|200px]]<br /><applet load="1e31" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1e31" size=" | + | |
caption="1e31, resolution 2.71Å" /> | caption="1e31, resolution 2.71Å" /> | ||
'''SURVIVIN DIMER H. SAPIENS'''<br /> | '''SURVIVIN DIMER H. SAPIENS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Survivin is a mitotic spindle-associated protein involved in linking | + | Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions. |
==About this Structure== | ==About this Structure== | ||
| - | 1E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and CO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CO:'>CO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:23:14 2008'' |
Revision as of 10:23, 21 February 2008
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SURVIVIN DIMER H. SAPIENS
Overview
Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.
About this Structure
1E31 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:10949039
Page seeded by OCA on Thu Feb 21 12:23:14 2008
Categories: Homo sapiens | Single protein | Chantalat, L. | Dideberg, O. | Margolis, R. | Skoufias, D. | CO | ZN | Apotosis | Iap | Zinc finger
