1e3g
From Proteopedia
(New page: 200px<br /> <applet load="1e3g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e3g, resolution 2.40Å" /> '''HUMAN ANDROGEN RECE...) |
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| - | [[Image:1e3g.gif|left|200px]]<br /> | + | [[Image:1e3g.gif|left|200px]]<br /><applet load="1e3g" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1e3g" size=" | + | |
caption="1e3g, resolution 2.40Å" /> | caption="1e3g, resolution 2.40Å" /> | ||
'''HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)'''<br /> | '''HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structures of the human androgen receptor (hAR) and human | + | The crystal structures of the human androgen receptor (hAR) and human progesterone receptor ligand-binding domains in complex with the same ligand metribolone (R1881) have been determined. Both three-dimensional structures show the typical nuclear receptor fold. The change of two residues in the ligand-binding pocket between the human progesterone receptor and hAR is most likely the source for the specificity of R1881 to the hAR. The structural implications of the 14 known mutations in the ligand-binding pocket of the hAR ligand-binding domains associated with either prostate cancer or the partial or complete androgen receptor insensitivity syndrome were analyzed. The effects of most of these mutants could be explained on the basis of the crystal structure. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1E3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with R18 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1E3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=R18:'>R18</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3G OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Basler, S.]] | [[Category: Basler, S.]] | ||
| - | [[Category: Carrondo, M | + | [[Category: Carrondo, M A.]] |
[[Category: Coelho, R.]] | [[Category: Coelho, R.]] | ||
[[Category: Donner, P.]] | [[Category: Donner, P.]] | ||
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[[Category: Joschko, S.]] | [[Category: Joschko, S.]] | ||
[[Category: Macedo, S.]] | [[Category: Macedo, S.]] | ||
| - | [[Category: Matias, P | + | [[Category: Matias, P M.]] |
[[Category: Otto, N.]] | [[Category: Otto, N.]] | ||
[[Category: Peixoto, C.]] | [[Category: Peixoto, C.]] | ||
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[[Category: ligand binding domain]] | [[Category: ligand binding domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:23:22 2008'' |
Revision as of 10:23, 21 February 2008
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HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)
Contents |
Overview
The crystal structures of the human androgen receptor (hAR) and human progesterone receptor ligand-binding domains in complex with the same ligand metribolone (R1881) have been determined. Both three-dimensional structures show the typical nuclear receptor fold. The change of two residues in the ligand-binding pocket between the human progesterone receptor and hAR is most likely the source for the specificity of R1881 to the hAR. The structural implications of the 14 known mutations in the ligand-binding pocket of the hAR ligand-binding domains associated with either prostate cancer or the partial or complete androgen receptor insensitivity syndrome were analyzed. The effects of most of these mutants could be explained on the basis of the crystal structure.
Disease
Known diseases associated with this structure: Androgen insensitivity OMIM:[313700], Breast cancer, male, with Reifenstein syndrome OMIM:[313700], Hypospadias, perineal OMIM:[313700], Prostate cancer OMIM:[313700], Prostate cancer, susceptibility to OMIM:[313700], Spinal and bulbar muscular atrophy of Kennedy OMIM:[313700]
About this Structure
1E3G is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations., Matias PM, Donner P, Coelho R, Thomaz M, Peixoto C, Macedo S, Otto N, Joschko S, Scholz P, Wegg A, Basler S, Schafer M, Egner U, Carrondo MA, J Biol Chem. 2000 Aug 25;275(34):26164-71. PMID:10840043
Page seeded by OCA on Thu Feb 21 12:23:22 2008
Categories: Homo sapiens | Single protein | Basler, S. | Carrondo, M A. | Coelho, R. | Donner, P. | Egner, U. | Joschko, S. | Macedo, S. | Matias, P M. | Otto, N. | Peixoto, C. | Ruff, M. | Schafer, M. | Scholz, P. | Thomaz, M. | Wegg, A. | R18 | Human androgen receptor | Ligand binding domain
