2rg6

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Revision as of 13:10, 26 July 2012

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Template:STRUCTURE 2rg6

Contents 1 Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J 2 About this Structure 3 See Also 4 Reference

Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J

Template:ABSTRACT PUBMED 18072718

About this Structure

2rg6 is a 1 chain structure of Mitogen-activated protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Mitogen-activated protein kinase

Reference

• Hynes J Jr, Dyckman AJ, Lin S, Wrobleski ST, Wu H, Gillooly KM, Kanner SB, Lonial H, Loo D, McIntyre KW, Pitt S, Shen DR, Shuster DJ, Yang X, Zhang R, Behnia K, Zhang H, Marathe PH, Doweyko AM, Tokarski JS, Sack JS, Pokross M, Kiefer SE, Newitt JA, Barrish JC, Dodd J, Schieven GL, Leftheris K. Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. J Med Chem. 2008 Jan 10;51(1):4-16. Epub 2007 Dec 12. PMID:18072718 doi:10.1021/jm7009414