1ed1
From Proteopedia
(New page: 200px<br /><applet load="1ed1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ed1, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1ed1.gif|left|200px]]<br /><applet load="1ed1" size=" | + | [[Image:1ed1.gif|left|200px]]<br /><applet load="1ed1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ed1, resolution 2.1Å" /> | caption="1ed1, resolution 2.1Å" /> | ||
'''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''<br /> | '''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Simian immunodeficiency virus (SIV) is closely related to human | + | Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA. |
==About this Structure== | ==About this Structure== | ||
| - | 1ED1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_mac Simian immunodeficiency virus - mac] with IPA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1ED1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_mac Simian immunodeficiency virus - mac] with <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Belyaev, A.]] | [[Category: Belyaev, A.]] | ||
[[Category: Fry, E.]] | [[Category: Fry, E.]] | ||
| - | [[Category: Jones, I | + | [[Category: Jones, I M.]] |
[[Category: Rao, Z.]] | [[Category: Rao, Z.]] | ||
[[Category: Roy, P.]] | [[Category: Roy, P.]] | ||
| - | [[Category: Stuart, D | + | [[Category: Stuart, D I.]] |
[[Category: IPA]] | [[Category: IPA]] | ||
[[Category: trimeric association]] | [[Category: trimeric association]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:28 2008'' |
Revision as of 10:26, 21 February 2008
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CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.
Overview
Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.
About this Structure
1ED1 is a Single protein structure of sequence from Simian immunodeficiency virus - mac with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:7501025
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