1edn
From Proteopedia
(New page: 200px<br /> <applet load="1edn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1edn, resolution 2.18Å" /> '''HUMAN ENDOTHELIN-1'...) |
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| - | [[Image:1edn.gif|left|200px]]<br /> | + | [[Image:1edn.gif|left|200px]]<br /><applet load="1edn" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1edn" size=" | + | |
caption="1edn, resolution 2.18Å" /> | caption="1edn, resolution 2.18Å" /> | ||
'''HUMAN ENDOTHELIN-1'''<br /> | '''HUMAN ENDOTHELIN-1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by | + | The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity. |
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| + | ==Disease== | ||
| + | Known disease associated with this structure: High density lipoprotein cholesterol level QTL 7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131240 131240]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 1EDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1EDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Janes, R | + | [[Category: Janes, R W.]] |
| - | [[Category: Wallace, B | + | [[Category: Wallace, B A.]] |
[[Category: signal polypeptide g-protein coupled-receptor ligand]] | [[Category: signal polypeptide g-protein coupled-receptor ligand]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:36 2008'' |
Revision as of 10:26, 21 February 2008
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HUMAN ENDOTHELIN-1
Contents |
Overview
The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.
Disease
Known disease associated with this structure: High density lipoprotein cholesterol level QTL 7 OMIM:[131240]
About this Structure
1EDN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human endothelin., Janes RW, Peapus DH, Wallace BA, Nat Struct Biol. 1994 May;1(5):311-9. PMID:7664037
Page seeded by OCA on Thu Feb 21 12:26:36 2008
