1usy
From Proteopedia
(New page: 200px<br /> <applet load="1usy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1usy, resolution 2.52Å" /> '''ATP PHOSPHORIBOSYL ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1USY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with PO4, HIS and HIS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USY OCA]]. | + | 1USY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with PO4, HIS and HIS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USY OCA]]. |
==Reference== | ==Reference== | ||
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit., Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M, Mol Microbiol. 2005 Feb;55(3):675-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15660995 15660995] | Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit., Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M, Mol Microbiol. 2005 Feb;55(3):675-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15660995 15660995] | ||
| + | [[Category: ATP phosphoribosyltransferase]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
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[[Category: atp phosphoribosyl transferase]] | [[Category: atp phosphoribosyl transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:56:11 2007'' |
Revision as of 11:51, 30 October 2007
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ATP PHOSPHORIBOSYL TRANSFERASE (HISG:HISZ) COMPLEX FROM THERMOTOGA MARITIMA
Overview
The molecular structure of the ATP phosphoribosyl transferase from the, hyperthermophile Thermotoga maritima is composed of a 220 kDa, hetero-octameric complex comprising four catalytic subunits (HisGS) and, four regulatory subunits (HisZ). Steady-state kinetics indicate that only, the complete octameric complex is active and non-competitively inhibited, by the pathway product histidine. The rationale for these findings is, provided by the crystal structure revealing a total of eight histidine, binding sites that are located within each of the four HisGS-HisZ subunit, interfaces formed by the ATP phosphoribosyl transferase complex. While the, structure of the catalytic HisGS subunit is related to the catalytic, domain of another family of (HisGL)2 ATP phosphoribosyl transferases that, is ... [(full description)]
About this Structure
1USY is a [Protein complex] structure of sequences from [Thermotoga maritima] with PO4, HIS and HIS as [ligands]. Active as [ATP phosphoribosyltransferase], with EC number [2.4.2.17]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit., Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M, Mol Microbiol. 2005 Feb;55(3):675-86. PMID:15660995
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