3e8n

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Revision as of 15:44, 26 July 2012

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Template:STRUCTURE 3e8n

Contents 1 X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP 2 About this Structure 3 See Also 4 Reference

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP

Template:ABSTRACT PUBMED 19706763

About this Structure

3e8n is a 1 chain structure of Ephrin receptor and Mitogen-activated protein kinase kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Ephrin receptor
• Mitogen-activated protein kinase kinase

Reference

• Iverson C, Larson G, Lai C, Yeh LT, Dadson C, Weingarten P, Appleby T, Vo T, Maderna A, Vernier JM, Hamatake R, Miner JN, Quart B. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47. Epub 2009 Aug 25. PMID:19706763 doi:10.1158/0008-5472.CAN-09-0679