1nc8
From Proteopedia
(New page: 200px<br /> <applet load="1nc8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nc8" /> '''HIGH-RESOLUTION SOLUTION NMR STRUCTURE OF T...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1NC8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1NC8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NC8 OCA]]. |
==Reference== | ==Reference== | ||
High-resolution solution NMR structure of the minimal active domain of the human immunodeficiency virus type-2 nucleocapsid protein., Kodera Y, Sato K, Tsukahara T, Komatsu H, Maeda T, Kohno T, Biochemistry. 1998 Dec 22;37(51):17704-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9922136 9922136] | High-resolution solution NMR structure of the minimal active domain of the human immunodeficiency virus type-2 nucleocapsid protein., Kodera Y, Sato K, Tsukahara T, Komatsu H, Maeda T, Kohno T, Biochemistry. 1998 Dec 22;37(51):17704-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9922136 9922136] | ||
| - | [[Category: Human immunodeficiency virus | + | [[Category: Human immunodeficiency virus 1]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kodera, Y.]] | [[Category: Kodera, Y.]] | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:57:11 2007'' |
Revision as of 11:52, 30 October 2007
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HIGH-RESOLUTION SOLUTION NMR STRUCTURE OF THE MINIMAL ACTIVE DOMAIN OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-2 NUCLEOCAPSID PROTEIN, 15 STRUCTURES
Overview
The retroviral nucleocapsid (NC) protein is a multifunctional protein, essential for RNA genome packaging and viral infectivity. The NC protein, NCp8, of the human immunodeficiency virus type-II (HIV-2) is a 49 amino, acid peptide containing two zinc fingers, of the type C-X2-C-X4-H-X4-C, connected by seven amino acid residues, called the "basic amino acid, cluster." It has been shown that the N-terminal zinc finger flanked by the, basic amino acid cluster is the minimal active domain for the specific, binding to viral RNA and other functions. However, the structure-activity, relationships of NCp8 have not been investigated in detail. In the present, study, the three-dimensional structure of a 29 amino acid peptide, including the minimal active domain (NCp8-fl), was determined by, ... [(full description)]
About this Structure
1NC8 is a [Single protein] structure of sequence from [Human immunodeficiency virus 1] with ZN as [ligand]. Structure known Active Site: ZNB. Full crystallographic information is available from [OCA].
Reference
High-resolution solution NMR structure of the minimal active domain of the human immunodeficiency virus type-2 nucleocapsid protein., Kodera Y, Sato K, Tsukahara T, Komatsu H, Maeda T, Kohno T, Biochemistry. 1998 Dec 22;37(51):17704-13. PMID:9922136
Page seeded by OCA on Tue Oct 30 13:57:11 2007
