3r92
From Proteopedia
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| - | [[Image:3r92. | + | [[Image:3r92.png|left|200px]] |
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{{STRUCTURE_3r92| PDB=3r92 | SCENE= }} | {{STRUCTURE_3r92| PDB=3r92 | SCENE= }} | ||
===Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.=== | ===Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.=== | ||
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{{ABSTRACT_PUBMED_21605975}} | {{ABSTRACT_PUBMED_21605975}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3r92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R92 OCA]. | + | [[3r92]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R92 OCA]. |
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| + | ==See Also== | ||
| + | *[[Heat Shock Proteins|Heat Shock Proteins]] | ||
==Reference== | ==Reference== | ||
Revision as of 16:52, 26 July 2012
Contents |
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Template:ABSTRACT PUBMED 21605975
About this Structure
3r92 is a 1 chain structure of Heat Shock Proteins with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Zapf CW, Bloom JD, McBean JL, Dushin RG, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Levin JI. Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3627-31. Epub 2011 Apr 28. PMID:21605975 doi:10.1016/j.bmcl.2011.04.102
Categories: Homo sapiens | Bloom, J D. | Boschelli, F. | Dushin, R G. | Golas, J M. | Levin, J I. | Liu, H. | Lucas, J. | McBean, J L. | Vogan, E M. | Zapf, C W. | Atp binding domain | Atp-binding | Chaperone | Chaperone-chaperone inhibitor complex | Nucleotide-binding | Phosphoprotein | Stress response
