1w96

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(New page: 200px<br /> <applet load="1w96" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w96, resolution 1.80&Aring;" /> '''CRYSTAL STRUCTURE O...)
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==About this Structure==
==About this Structure==
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1W96 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with S1A as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.2 6.4.1.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W96 OCA]].
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1W96 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with S1A as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Acetyl-CoA_carboxylase Acetyl-CoA carboxylase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.2 6.4.1.2]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W96 OCA]].
==Reference==
==Reference==
A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product., Shen Y, Volrath SL, Weatherly SC, Elich TD, Tong L, Mol Cell. 2004 Dec 22;16(6):881-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15610732 15610732]
A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product., Shen Y, Volrath SL, Weatherly SC, Elich TD, Tong L, Mol Cell. 2004 Dec 22;16(6):881-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15610732 15610732]
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[[Category: Acetyl-CoA carboxylase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: structure-based drug design]]
[[Category: structure-based drug design]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:21:59 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:57:43 2007''

Revision as of 11:53, 30 October 2007


1w96, resolution 1.80Å

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CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE DOMAIN OF ACETYL-COENZYME A CARBOXYLASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH SORAPHEN A

Overview

Acetyl-coenzyme A carboxylases (ACCs) have crucial roles in fatty acid, metabolism. Soraphen A, a macrocyclic polyketide natural product, is a, nanomolar inhibitor against the biotin carboxylase (BC) domain of human, yeast, and other eukaryotic ACCs. Here we report the crystal structures of, the yeast BC domain, alone and in complex with soraphen A. Soraphen has, extensive interactions with an allosteric site, about 25 A from the active, site. The specificity of soraphen is explained by large structural, differences between the eukaryotic and prokaryotic BC in its binding site, confirmed by our studies on the effects of single-site mutations in this, binding site. Unexpectedly, our structures suggest that soraphen may bind, in the BC dimer interface and inhibit the BC activity by ... [(full description)]

About this Structure

1W96 is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with S1A as [ligand]. Active as [Acetyl-CoA carboxylase], with EC number [6.4.1.2]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product., Shen Y, Volrath SL, Weatherly SC, Elich TD, Tong L, Mol Cell. 2004 Dec 22;16(6):881-91. PMID:15610732

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