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1hxb
From Proteopedia
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[[Image:1hxb.png|left|200px]] | [[Image:1hxb.png|left|200px]] | ||
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{{STRUCTURE_1hxb| PDB=1hxb | SCENE= }} | {{STRUCTURE_1hxb| PDB=1hxb | SCENE= }} | ||
| - | ===HIV-1 | + | ===HIV-1 proteinase complexed with RO 31-8959=== |
==About this Structure== | ==About this Structure== | ||
| - | + | [[1hxb]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. The June 2000 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''HIV-1 Protease'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2000_6 10.2210/rcsb_pdb/mom_2000_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXB OCA]. | |
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| + | ==See Also== | ||
| + | *[[Virus protease|Virus protease]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:001956054</ref><ref group="xtra">PMID:002183354</ref><ref group="xtra">PMID:011106162</ref><references group="xtra"/> |
[[Category: HIV-1 Protease]] | [[Category: HIV-1 Protease]] | ||
[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
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[[Category: Graves, B J.]] | [[Category: Graves, B J.]] | ||
[[Category: Hatada, M H.]] | [[Category: Hatada, M H.]] | ||
| - | [[Category: | + | [[Category: Aspartyl protease]] |
| - | + | [[Category: Hydrolase-hydrolase inhibitor complex]] | |
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Revision as of 17:34, 26 July 2012
Contents |
HIV-1 proteinase complexed with RO 31-8959
About this Structure
1hxb is a 2 chain structure of Virus protease with sequence from Viruses. The June 2000 RCSB PDB Molecule of the Month feature on HIV-1 Protease by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_6. Full crystallographic information is available from OCA.
See Also
Reference
- Krohn A, Redshaw S, Ritchie JC, Graves BJ, Hatada MH. Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere. J Med Chem. 1991 Nov;34(11):3340-2. PMID:1956054
- Roberts NA, Martin JA, Kinchington D, Broadhurst AV, Craig JC, Duncan IB, Galpin SA, Handa BK, Kay J, Krohn A, et al.. Rational design of peptide-based HIV proteinase inhibitors. Science. 1990 Apr 20;248(4953):358-61. PMID:2183354
- Hong L, Zhang XC, Hartsuck JA, Tang J. Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance. Protein Sci. 2000 Oct;9(10):1898-904. PMID:11106162
