1hxb

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Revision as of 17:34, 26 July 2012

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Template:STRUCTURE 1hxb

Contents 1 HIV-1 proteinase complexed with RO 31-8959 2 About this Structure 3 See Also 4 Reference

HIV-1 proteinase complexed with RO 31-8959

About this Structure

1hxb is a 2 chain structure of Virus protease with sequence from Viruses. The June 2000 RCSB PDB Molecule of the Month feature on HIV-1 Protease by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_6. Full crystallographic information is available from OCA.

See Also

• Virus protease

Reference

• Krohn A, Redshaw S, Ritchie JC, Graves BJ, Hatada MH. Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere. J Med Chem. 1991 Nov;34(11):3340-2. PMID:1956054
• Roberts NA, Martin JA, Kinchington D, Broadhurst AV, Craig JC, Duncan IB, Galpin SA, Handa BK, Kay J, Krohn A, et al.. Rational design of peptide-based HIV proteinase inhibitors. Science. 1990 Apr 20;248(4953):358-61. PMID:2183354
• Hong L, Zhang XC, Hartsuck JA, Tang J. Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance. Protein Sci. 2000 Oct;9(10):1898-904. PMID:11106162