This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3hk3
From Proteopedia
(Difference between revisions)
m (Protected "3hk3" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:3hk3.png|left|200px]] | [[Image:3hk3.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3hk3", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3hk3| PDB=3hk3 | SCENE= }} | {{STRUCTURE_3hk3| PDB=3hk3 | SCENE= }} | ||
===Crystal structure of murine thrombin mutant W215A/E217A (one molecule in the asymmetric unit)=== | ===Crystal structure of murine thrombin mutant W215A/E217A (one molecule in the asymmetric unit)=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_19586901}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 19586901 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_19586901}} | {{ABSTRACT_PUBMED_19586901}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3hk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK3 OCA]. | + | [[3hk3]] is a 2 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK3 OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019586901</ref><ref group="xtra">PMID:015252033</ref><references group="xtra"/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
| Line 32: | Line 24: | ||
[[Category: Acute phase]] | [[Category: Acute phase]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
Revision as of 17:34, 26 July 2012
Contents |
Crystal structure of murine thrombin mutant W215A/E217A (one molecule in the asymmetric unit)
Template:ABSTRACT PUBMED 19586901
About this Structure
3hk3 is a 2 chain structure of Thrombin with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403
- Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200
