1eqy

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(New page: 200px<br /> <applet load="1eqy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1eqy, resolution 2.3&Aring;" /> '''COMPLEX BETWEEN RABB...)
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[[Image:1eqy.gif|left|200px]]<br /><applet load="1eqy" size="350" color="white" frame="true" align="right" spinBox="true"
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<applet load="1eqy" size="450" color="white" frame="true" align="right" spinBox="true"
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caption="1eqy, resolution 2.3&Aring;" />
'''COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1'''<br />
'''COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1'''<br />
==Overview==
==Overview==
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The structure of the segment 1 domain of gelsolin, a protein that, fragments actin filaments in cells, is reported in complex with actin., Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in, a cleft between actin domains. On the actin filament model it binds, tangentially, disrupting only those contacts between adjacent subunits in, one helical strand. The segment 1 fold is general for all segments of the, gelsolin family because the conserved residues form the core of the, structure. It also provides a basis for understanding the origin of an, amyloidosis caused by a gelsolin variant.
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The structure of the segment 1 domain of gelsolin, a protein that fragments actin filaments in cells, is reported in complex with actin. Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in a cleft between actin domains. On the actin filament model it binds tangentially, disrupting only those contacts between adjacent subunits in one helical strand. The segment 1 fold is general for all segments of the gelsolin family because the conserved residues form the core of the structure. It also provides a basis for understanding the origin of an amyloidosis caused by a gelsolin variant.
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1EQY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with CA and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EQY OCA].
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1EQY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQY OCA].
==Reference==
==Reference==
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Gooch, J.T.]]
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[[Category: Gooch, J T.]]
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[[Category: Mannherz, H.G.]]
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[[Category: Mannherz, H G.]]
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[[Category: McLaughlin, P.J.]]
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[[Category: McLaughlin, P J.]]
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[[Category: Weeds, A.G.]]
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[[Category: Weeds, A G.]]
[[Category: ATP]]
[[Category: ATP]]
[[Category: CA]]
[[Category: CA]]
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[[Category: gelsolin]]
[[Category: gelsolin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:45:51 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:37 2008''

Revision as of 10:30, 21 February 2008

Image:1eqy.gif

1eqy, resolution 2.3Å

Drag the structure with the mouse to rotate

COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1

Contents

Overview

The structure of the segment 1 domain of gelsolin, a protein that fragments actin filaments in cells, is reported in complex with actin. Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in a cleft between actin domains. On the actin filament model it binds tangentially, disrupting only those contacts between adjacent subunits in one helical strand. The segment 1 fold is general for all segments of the gelsolin family because the conserved residues form the core of the structure. It also provides a basis for understanding the origin of an amyloidosis caused by a gelsolin variant.

Disease

Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]

About this Structure

1EQY is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus with and as ligands. Full crystallographic information is available from OCA.

Reference

Structure of gelsolin segment 1-actin complex and the mechanism of filament severing., McLaughlin PJ, Gooch JT, Mannherz HG, Weeds AG, Nature. 1993 Aug 19;364(6439):685-92. PMID:8395021

Page seeded by OCA on Thu Feb 21 12:30:37 2008

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