1et1
From Proteopedia
(New page: 200px<br /> <applet load="1et1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1et1, resolution 0.90Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1et1.gif|left|200px]]<br /> | + | [[Image:1et1.gif|left|200px]]<br /><applet load="1et1" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1et1" size=" | + | |
caption="1et1, resolution 0.90Å" /> | caption="1et1, resolution 0.90Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered | + | The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define more precisely the ligand-receptor interactions, we have crystallized human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution. hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis reveals that the extended helical conformation of hPTH-(1-34) is the likely bioactive conformation. We have developed molecular models for the interaction of hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor. A receptor binding pocket for the N terminus of hPTH-(1-34) and a hydrophobic interface with the receptor for the C terminus of hPTH-(1-34) are proposed. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ET1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1ET1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ET1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Briggs, S | + | [[Category: Briggs, S L.]] |
[[Category: Chandrasekhar, S.]] | [[Category: Chandrasekhar, S.]] | ||
| - | [[Category: Chirgadze, N | + | [[Category: Chirgadze, N Y.]] |
| - | [[Category: Clawson, D | + | [[Category: Clawson, D K.]] |
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
| - | [[Category: Schevitz, R | + | [[Category: Schevitz, R W.]] |
| - | [[Category: Smiley, D | + | [[Category: Smiley, D L.]] |
| - | [[Category: Tashjian, A | + | [[Category: Tashjian, A H.]] |
[[Category: Zhang, F.]] | [[Category: Zhang, F.]] | ||
[[Category: NA]] | [[Category: NA]] | ||
[[Category: helical dimer]] | [[Category: helical dimer]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:31:13 2008'' |
Revision as of 10:31, 21 February 2008
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CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION
Contents |
Overview
The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define more precisely the ligand-receptor interactions, we have crystallized human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution. hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis reveals that the extended helical conformation of hPTH-(1-34) is the likely bioactive conformation. We have developed molecular models for the interaction of hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor. A receptor binding pocket for the N terminus of hPTH-(1-34) and a hydrophobic interface with the receptor for the C terminus of hPTH-(1-34) are proposed.
Disease
Known diseases associated with this structure: Hypoparathyroidism, autosomal dominant OMIM:[168450], Hypoparathyroidism, autosomal recessive OMIM:[168450]
About this Structure
1ET1 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution., Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F, J Biol Chem. 2000 Sep 1;275(35):27238-44. PMID:10837469
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