1w8j
From Proteopedia
(New page: 200px<br /> <applet load="1w8j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w8j, resolution 2.7Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W8J is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8J OCA]]. | + | 1W8J is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8J OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: unconventional myosin]] | [[Category: unconventional myosin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:58:39 2007'' |
Revision as of 11:53, 30 October 2007
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CRYSTAL STRUCTURE OF MYOSIN V MOTOR DOMAIN-NUCLEOTIDE-FREE
Overview
The molecular motor, myosin, undergoes conformational changes in order to, convert chemical energy into force production. Based on kinetic and, structural considerations, we assert that three crystal forms of the, myosin V motor delineate the conformational changes that myosin motors, undergo upon detachment from actin. First, a motor domain structure, demonstrates that nucleotide-free myosin V adopts a specific state, (rigor-like) that is not influenced by crystal packing. A second structure, reveals an actomyosin state that favors rapid release of ADP, and differs, from the rigor-like state by a P-loop rearrangement. Comparison of these, structures with a third structure, a 2.0 angstroms resolution structure of, the motor bound to an ATP analog, illuminates the structural features that, ... [(full description)]
About this Structure
1W8J is a [Single protein] structure of sequence from [Gallus gallus] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Three myosin V structures delineate essential features of chemo-mechanical transduction., Coureux PD, Sweeney HL, Houdusse A, EMBO J. 2004 Nov 24;23(23):4527-37. Epub 2004 Oct 28. PMID:15510214
Page seeded by OCA on Tue Oct 30 13:58:39 2007
