2phb
From Proteopedia
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[[Image:2phb.png|left|200px]] | [[Image:2phb.png|left|200px]] | ||
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{{STRUCTURE_2phb| PDB=2phb | SCENE= }} | {{STRUCTURE_2phb| PDB=2phb | SCENE= }} | ||
===An Orally Efficacious Factor Xa Inhibitor=== | ===An Orally Efficacious Factor Xa Inhibitor=== | ||
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{{ABSTRACT_PUBMED_17683371}} | {{ABSTRACT_PUBMED_17683371}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227600 227600]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2phb]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHB OCA]. | |
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| + | ==See Also== | ||
| + | *[[Factor Xa|Factor Xa]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017683371</ref><references group="xtra"/> |
[[Category: Coagulation factor Xa]] | [[Category: Coagulation factor Xa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Blood clotting]] | [[Category: Blood clotting]] | ||
[[Category: Fxa coagulation factor inhibitor]] | [[Category: Fxa coagulation factor inhibitor]] | ||
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Revision as of 18:38, 26 July 2012
Contents |
An Orally Efficacious Factor Xa Inhibitor
Template:ABSTRACT PUBMED 17683371
About this Structure
2phb is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Kohrt JT, Bigge CF, Bryant JW, Casimiro-Garcia A, Chi L, Cody WL, Dahring T, Dudley DA, Filipski KJ, Haarer S, Heemstra R, Janiczek N, Narasimhan L, McClanahan T, Peterson JT, Sahasrabudhe V, Schaum R, Van Huis CA, Welch KM, Zhang E, Leadley RJ, Edmunds JJ. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarb oxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chem Biol Drug Des. 2007 Aug;70(2):100-12. PMID:17683371 doi:10.1111/j.1747-0285.2007.00539.x
