2phb

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Revision as of 18:38, 26 July 2012

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Template:STRUCTURE 2phb

Contents 1 An Orally Efficacious Factor Xa Inhibitor 2 About this Structure 3 See Also 4 Reference

An Orally Efficacious Factor Xa Inhibitor

Template:ABSTRACT PUBMED 17683371

About this Structure

2phb is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Factor Xa

Reference

• Kohrt JT, Bigge CF, Bryant JW, Casimiro-Garcia A, Chi L, Cody WL, Dahring T, Dudley DA, Filipski KJ, Haarer S, Heemstra R, Janiczek N, Narasimhan L, McClanahan T, Peterson JT, Sahasrabudhe V, Schaum R, Van Huis CA, Welch KM, Zhang E, Leadley RJ, Edmunds JJ. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarb oxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chem Biol Drug Des. 2007 Aug;70(2):100-12. PMID:17683371 doi:10.1111/j.1747-0285.2007.00539.x