2w0j
From Proteopedia
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[[Image:2w0j.png|left|200px]] | [[Image:2w0j.png|left|200px]] | ||
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===CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR=== | ===CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR=== | ||
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{{ABSTRACT_PUBMED_19177354}} | {{ABSTRACT_PUBMED_19177354}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2w0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0J OCA]. | + | [[2w0j]] is a 1 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0J OCA]. |
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| + | ==See Also== | ||
| + | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019177354</ref><ref group="xtra">PMID:017616632</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
Revision as of 18:48, 26 July 2012
Contents |
CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR
Template:ABSTRACT PUBMED 19177354
About this Structure
2w0j is a 1 chain structure of Serine/threonine protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci. 2009 Jan;18(1):92-100. PMID:19177354 doi:10.1002/pro.16
- Jobson AG, Cardellina JH 2nd, Scudiero D, Kondapaka S, Zhang H, Kim H, Shoemaker R, Pommier Y. Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol. 2007 Oct;72(4):876-84. Epub 2007 Jul 6. PMID:17616632 doi:10.1124/mol.107.035832
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Jobson, A G. | Lountos, G T. | Pommier, Y. | Shoemaker, R H. | Tropea, J E. | Waugh, D S. | Zhang, D. | Chk2 inhibitor | Kinase | Li-fraumeni syndrome | Nucleotide-binding | Oncology | Serine/threonine-protein kinase | Structure-assisted drug design | Transferase
