1ew4
From Proteopedia
(New page: 200px<br /><applet load="1ew4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ew4, resolution 1.40Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1ew4.gif|left|200px]]<br /><applet load="1ew4" size=" | + | [[Image:1ew4.gif|left|200px]]<br /><applet load="1ew4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ew4, resolution 1.40Å" /> | caption="1ew4, resolution 1.40Å" /> | ||
'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY'''<br /> | '''CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Friedreich ataxia is an autosomal recessive neurodegenerative disease | + | Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of gamma-purple bacteria are believed to be closely related to the ancestor of frataxin. In this study, we have determined the crystal structure of the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a protein fold consisting of a six-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This fold is likely to be shared by all members of the conserved frataxin family. This study also provides a framework for the interpretation of disease-associated mutations in frataxin and for understanding the possible functions of this protein family. |
==About this Structure== | ==About this Structure== | ||
| - | 1EW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1EW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cho, S.]] | [[Category: Cho, S.]] | ||
| - | [[Category: Lee, J | + | [[Category: Lee, J Y.]] |
| - | [[Category: Lee, M | + | [[Category: Lee, M G.]] |
| - | [[Category: Song, H | + | [[Category: Song, H K.]] |
| - | [[Category: Suh, S | + | [[Category: Suh, S W.]] |
| - | [[Category: Yang, J | + | [[Category: Yang, J K.]] |
[[Category: cyay]] | [[Category: cyay]] | ||
[[Category: frataxin family]] | [[Category: frataxin family]] | ||
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[[Category: iron homeostasis]] | [[Category: iron homeostasis]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:32:09 2008'' |
Revision as of 10:32, 21 February 2008
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY
Overview
Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of gamma-purple bacteria are believed to be closely related to the ancestor of frataxin. In this study, we have determined the crystal structure of the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a protein fold consisting of a six-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This fold is likely to be shared by all members of the conserved frataxin family. This study also provides a framework for the interpretation of disease-associated mutations in frataxin and for understanding the possible functions of this protein family.
About this Structure
1EW4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family., Cho SJ, Lee MG, Yang JK, Lee JY, Song HK, Suh SW, Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8932-7. PMID:10908679
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