2r3q
From Proteopedia
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[[Image:2r3q.png|left|200px]] | [[Image:2r3q.png|left|200px]] | ||
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{{STRUCTURE_2r3q| PDB=2r3q | SCENE= }} | {{STRUCTURE_2r3q| PDB=2r3q | SCENE= }} | ||
===Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor=== | ===Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor=== | ||
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==See Also== | ==See Also== | ||
| - | *[[Cell Division Protein Kinase 2]] | + | *[[Cell Division Protein Kinase 2|Cell Division Protein Kinase 2]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017937404</ref><ref group="xtra">PMID:017904366</ref><ref group="xtra">PMID:017904841</ref><references group="xtra"/> |
[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 19:08, 26 July 2012
Contents |
Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor
Template:ABSTRACT PUBMED 17937404
About this Structure
2r3q is a 1 chain structure of Cell Division Protein Kinase 2 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Fischmann TO, Hruza A, Duca JS, Ramanathan L, Mayhood T, Windsor WT, Le HV, Guzi TJ, Dwyer MP, Paruch K, Doll RJ, Lees E, Parry D, Seghezzi W, Madison V. Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers. 2007 Oct 15;. PMID:17937404 doi:http://dx.doi.org/10.1002/bip.20868
- Dwyer MP, Paruch K, Alvarez C, Doll RJ, Keertikar K, Duca J, Fischmann TO, Hruza A, Madison V, Lees E, Parry D, Seghezzi W, Sgambellone N, Shanahan F, Wiswell D, Guzi TJ. Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6216-9. Epub 2007 Sep 8. PMID:17904366 doi:http://dx.doi.org/10.1016/j.bmcl.2007.09.018
- Paruch K, Dwyer MP, Alvarez C, Brown C, Chan TY, Doll RJ, Keertikar K, Knutson C, McKittrick B, Rivera J, Rossman R, Tucker G, Fischmann TO, Hruza A, Madison V, Nomeir AA, Wang Y, Lees E, Parry D, Sgambellone N, Seghezzi W, Schultz L, Shanahan F, Wiswell D, Xu X, Zhou Q, James RA, Paradkar VM, Park H, Rokosz LR, Stauffer TM, Guzi TJ. Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6220-3. Epub 2007 Sep 8. PMID:17904841 doi:10.1016/j.bmcl.2007.09.017
