1exb
From Proteopedia
(New page: 200px<br /><applet load="1exb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1exb, resolution 2.1Å" /> '''STRUCTURE OF THE CYTO...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1exb.gif|left|200px]]<br /><applet load="1exb" size=" | + | [[Image:1exb.gif|left|200px]]<br /><applet load="1exb" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1exb, resolution 2.1Å" /> | caption="1exb, resolution 2.1Å" /> | ||
'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''<br /> | '''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the cytoplasmic assembly of voltage-dependent K+ channels | + | The structure of the cytoplasmic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane alpha subunit together with the oxidoreductase beta subunit in a fourfold symmetric T1(4)beta4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four beta subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1(4)beta4 complex. The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings. |
==About this Structure== | ==About this Structure== | ||
| - | 1EXB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with NDP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1EXB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NDP:'>NDP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXB OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Gulbis, J | + | [[Category: Gulbis, J M.]] |
[[Category: MacKinnon, R.]] | [[Category: MacKinnon, R.]] | ||
[[Category: Mann, S.]] | [[Category: Mann, S.]] | ||
| Line 22: | Line 22: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:32:27 2008'' |
Revision as of 10:32, 21 February 2008
|
STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS
Overview
The structure of the cytoplasmic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane alpha subunit together with the oxidoreductase beta subunit in a fourfold symmetric T1(4)beta4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four beta subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1(4)beta4 complex. The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings.
About this Structure
1EXB is a Protein complex structure of sequences from Rattus norvegicus with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:10884227
Page seeded by OCA on Thu Feb 21 12:32:27 2008
