3cv9
From Proteopedia
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[[Image:3cv9.png|left|200px]] | [[Image:3cv9.png|left|200px]] | ||
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===Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3=== | ===Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3=== | ||
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==See Also== | ==See Also== | ||
| - | *[[Cytochrome P450]] | + | *[[Cytochrome P450|Cytochrome P450]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018937506</ref><ref group="xtra">PMID:018314962</ref><ref group="xtra">PMID:020731719</ref><references group="xtra"/> |
[[Category: Streptomyces griseolus]] | [[Category: Streptomyces griseolus]] | ||
[[Category: Unspecific monooxygenase]] | [[Category: Unspecific monooxygenase]] | ||
Revision as of 19:18, 26 July 2012
Contents |
Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3
Template:ABSTRACT PUBMED 18937506
About this Structure
3cv9 is a 1 chain structure of Cytochrome P450 with sequence from Streptomyces griseolus. Full crystallographic information is available from OCA.
See Also
Reference
- Hayashi K, Sugimoto H, Shinkyo R, Yamada M, Ikeda S, Ikushiro S, Kamakura M, Shiro Y, Sakaki T. Structure-Based Design of a Highly Active Vitamin D Hydroxylase from Streptomyces griseolus CYP105A1. Biochemistry. 2008 Oct 21. PMID:18937506 doi:10.1021/bi801222d
- Sugimoto H, Shinkyo R, Hayashi K, Yoneda S, Yamada M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T. Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3(,). Biochemistry. 2008 Apr 1;47(13):4017-27. Epub 2008 Mar 4. PMID:18314962 doi:http://dx.doi.org/10.1021/bi7023767
- Hayashi K, Yasuda K, Sugimoto H, Ikushiro S, Kamakura M, Kittaka A, Horst RL, Chen TC, Ohta M, Shiro Y, Sakaki T. Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis. FEBS J. 2010 Oct;277(19):3999-4009. doi: 10.1111/j.1742-4658.2010.07791.x., Epub 2010 Aug 20. PMID:20731719 doi:10.1111/j.1742-4658.2010.07791.x
