1f37
From Proteopedia
(New page: 200px<br /><applet load="1f37" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f37, resolution 2.3Å" /> '''STRUCTURE OF A THIORE...) |
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| - | [[Image:1f37.jpg|left|200px]]<br /><applet load="1f37" size=" | + | [[Image:1f37.jpg|left|200px]]<br /><applet load="1f37" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1f37, resolution 2.3Å" /> | caption="1f37, resolution 2.3Å" /> | ||
'''STRUCTURE OF A THIOREDOXIN-LIKE [2FE-2S] FERREDOXIN FROM AQUIFEX AEOLICUS'''<br /> | '''STRUCTURE OF A THIOREDOXIN-LIKE [2FE-2S] FERREDOXIN FROM AQUIFEX AEOLICUS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The 2.3 A resolution crystal structure of a [2Fe-2S] cluster containing | + | The 2.3 A resolution crystal structure of a [2Fe-2S] cluster containing ferredoxin from Aquifex aeolicus reveals a thioredoxin-like fold that is novel among iron-sulfur proteins. The [2Fe-2S] cluster is located near the surface of the protein, at a site corresponding to that of the active-site disulfide bridge in thioredoxin. The four cysteine ligands are located near the ends of two surface loops. Two of these ligands can be substituted by non-native cysteine residues introduced throughout a stretch of the polypeptide chain that forms a protruding loop extending away from the cluster. The presence of homologs of this ferredoxin as components of more complex anaerobic and aerobic electron transfer systems indicates that this is a versatile fold for biological redox processes. |
==About this Structure== | ==About this Structure== | ||
| - | 1F37 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with FES and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1F37 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=FES:'>FES</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F37 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Kuhn, P.]] | [[Category: Kuhn, P.]] | ||
[[Category: Meyer, J.]] | [[Category: Meyer, J.]] | ||
| - | [[Category: Rees, D | + | [[Category: Rees, D C.]] |
| - | [[Category: Soltis, S | + | [[Category: Soltis, S M.]] |
| - | [[Category: Yeh, A | + | [[Category: Yeh, A P.]] |
[[Category: FES]] | [[Category: FES]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: thioredoxin fold]] | [[Category: thioredoxin fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:20 2008'' |
Revision as of 10:34, 21 February 2008
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STRUCTURE OF A THIOREDOXIN-LIKE [2FE-2S] FERREDOXIN FROM AQUIFEX AEOLICUS
Overview
The 2.3 A resolution crystal structure of a [2Fe-2S] cluster containing ferredoxin from Aquifex aeolicus reveals a thioredoxin-like fold that is novel among iron-sulfur proteins. The [2Fe-2S] cluster is located near the surface of the protein, at a site corresponding to that of the active-site disulfide bridge in thioredoxin. The four cysteine ligands are located near the ends of two surface loops. Two of these ligands can be substituted by non-native cysteine residues introduced throughout a stretch of the polypeptide chain that forms a protruding loop extending away from the cluster. The presence of homologs of this ferredoxin as components of more complex anaerobic and aerobic electron transfer systems indicates that this is a versatile fold for biological redox processes.
About this Structure
1F37 is a Single protein structure of sequence from Aquifex aeolicus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of a thioredoxin-like [2Fe-2S] ferredoxin from Aquifex aeolicus., Yeh AP, Chatelet C, Soltis SM, Kuhn P, Meyer J, Rees DC, J Mol Biol. 2000 Jul 14;300(3):587-95. PMID:10884354[[Category: [2fe-2s] cluster]]
Page seeded by OCA on Thu Feb 21 12:34:20 2008
Categories: Aquifex aeolicus | Single protein | Chatelet, C. | Kuhn, P. | Meyer, J. | Rees, D C. | Soltis, S M. | Yeh, A P. | FES | GOL | Ferredoxin | Thioredoxin fold
